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. 2020 Aug 23;72(7):1268–1278. doi: 10.1093/cid/ciaa1243

Table 3.

Summary of Diagnostic Accuracy Findings

		Quantity of evidence		Summary estimates
Sample	Test type	Cohorts, n	Participants, n	Sensitivity, % (95% CI)	Specificity, % (95% CI)
Serum	LA	5	256	100 (99.5–100)^a	96.7 (93.8–98.9)^a
	LFA	3	1690	97.9 (87.9–100)^a	89.5 (74.3–98.5)^a
	Overall serum CrAg	8	1946	99.7 (97.4–100)^b	94.1 (88.3–98.1)^b
	P value^c	8	-	.08	.16
CSF	LA	10	1810	97.1 (91.9–99.0)^b	99.1 (93.8–99.9)^b
	LFA	6	3099	99.5 (97.2–99.9)^b	99.5 (94.2–100)^b
	Overall CSF CrAg	16	3500	98.8 (96.2–99.6)^b	99.3 (96.7–99.9)^b
	P value^c	16	-	.07	.54

Abbreviations: CI, confidence interval; CrAg, cryptococcal antigen; CSF, cerebrospinal fluid; LA, latex agglutination; LFA, lateral flow assay.

^aUnivariate random-effects model.

^bBivariate random-effects model.

^cUnivariate logit-normal random-effects meta-regression model.