Table 1.
Patient Characteristics of ICU Patients of the University Medical Center Hamburg-Eppendorf, Hamburg, Germany
| Survivors, No. (%) or Median (IQR) (n=100) | Nonsurvivors, No. (%) or Median (IQR) (n=70) | Comparative Statistics, P Value | Total, No. (%) or Median (IQR) (n=170) | |
|---|---|---|---|---|
| Age, y | 60 (51–72) | 67 (59–76) | .01 | 63 (55–73) |
| Sex | Male: 63 (63) | Male: 48 (69) | .45 | Male:111 (65) |
| Female:37 (37) | Female: 22 (31) | Female: 59 (35) | ||
| Body mass index, kg/m2 | 28 (25–32) | 26 (24–32) | .22 | 27 (25–32) |
| Charlson comorbidity index at ICU admission | 1 (1–3) | 2 (1–4) | .05 | 2 (1–3) |
| Comorbidities | ||||
| Chronic lung disease | 13 (13) | 11 (16) | .62 | 24 (14) |
| Type II diabetes mellitus | 35 (35) | 23 (33) | .77 | 58 (34) |
| Arterial hypertension | 55 (55) | 43 (61) | .40 | 98 (58) |
| Immunosupression | 23 (23) | 28 (40) | .02 | 51 (30) |
| Duration of illness/time from COVID-19 diagnosis until ICU admission, d | 3 (1–8) | 7 (1–13) | .14 | 4 (1–11) |
| COVID-19 disease severity | ||||
| Clinically diagnosed ARDS | 50 (50) | 63 (90) | <.0001 | 113 (67) |
| Sepsis-related Organ Failure Assessment Score | 5 (3–11) | 10 (5–13) | .001 | 7 (3–12) |
| Simplified Acute Physiology Score II | 37 (30–43) | 42 (37–52) | <.0001 | 40 (32–48) |
| ICU-specific treatment | ||||
| Mechanical ventilation | 57 (57) | 65 (93) | <.0001 | 122 (72) |
| ECMO | 17 (17) | 32 (46) | <.0001 | 49 (29) |
| COVID-19-related treatment | ||||
| Dexamethasone | 39 (39) | 35 (50) | .16 | 74 (44) |
| Remdesivir | 22 (22) | 11 (16) | .31 | 33 (19) |
| Monoclonal antibodies | 0 (0) | 3 (4) | .07 | 3 (2) |
| Therapeutic plasma exchange | 3 (3) | 3 (4) | .69 | 6 (4) |
The groups are divided according to survival.
Abbreviations: ARDS, acute respiratory distress syndrome; COVID-19, coronavirus disease 2019; ECMO, extracorporeal membrane oxygenation; ICU, intensive care unit.