Table 2.

Predictors of MyCog total score in n=420

	Coefficient and 95% CI for each model
	Model 1	Model 2	Model 3	Model 4	Model 5	Model 6	Model 7
Amyloid status (negative as reference)	0.85 (-0.10 to 1.81)	0.95 (0.03 to 1.87) *	0.95 (0.03 to 1.87) *	0.89 (-0.01 to 1.78)	0.82 (-0.09 to 1.73)	0.70 (-0.23 to 1.64)	0.67 (-0.27 to 1.62)
Age	0.07 (-0.46 to 0.61)	0.05 (-0.48 to 0.57)	0.05 (-0.48 to 0.58)	0.05 (-0.49 to 0.60)	0.04 (-0.49 to 0.58)	0.19 (-0.37 to 0.75)	0.18 (-0.38 to 0.74)
Sex (male as reference)	0.19 (-0.54 to 0.92)	−0.10 (-0.80 to 0.60)	−0.10 (-0.80 to 0.60)	−0.14 (-0.85 to 0.56)	0.0005 (-0.71 to 0.71)	−0.03 (-0.84 to 0.77)	−0.03 (-0.83 to 0.78)
Trait anxiety		0.14 (0.08 to 0.19) †	0.14 (0.08 to 0.20) †	0.13 (0.07 to 0.19) †	0.13 (0.07 to 0.19) †	0.14 (0.08 to 0.21) †	0.14 (0.08 to 0.21) †
State anxiety			−0.002 (-0.05 to 0.05)	−0.003 (-0.06 to 0.05)	−0.007 (-0.06 to 0.05)	−0.02 (-0.07 to 0.04)	−0.02 (-0.07 to 0.04)
Mental health disorder (no as reference)				1.10 (-1.00 to 3.20)	1.05 (-1.02 to 3.11)	1.21 (-0.87 to 3.29)	1.20 (-0.90 to 3.29)
PACC z-score					−0.40 (-1.00 to 0.20)	−0.47 (-1.28 to 0.33)	−0.48 (-1.29 to 0.33)
Childhood cognitive ability						0.15 (-0.42 to 0.71)	0.14 (-0.43 to 0.71)
Education (per category)						0.12 (-0.25 to 0.48)	0.11 (-0.26 to 0.48)
SEP (per category)						0.02 (-0.41 to 0.45)	0.02 (-0.41 to 0.45)
Family history of dementia (no as reference)							0.25 (-0.67 to 1.17)
R2	0.008	0.084	0.084	0.088	0.093	0.102	0.103

Multivariable regression models were used so each association is independent of all others. R² gives the proportion of variance in each cognitive outcome that is explained by the combined predictors.

*Significant at p<0.05;

†Significant at p<0.01.

PACC, Preclinical Alzheimer Cognitive Composite; SEP, socioeconomic position.