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Profile of ATXN2 repeat expansions in 977 Irish patients with ALS and 562 population-matched healthy controls. (A) Allele frequencies for ALS cases and controls for the larger ATXN2 allele observed per individual. (B) OR ±95% CI for ATXN2 repeat expansions in ALS, thresholded by each observed allele as a lower limit. Asterisks indicate repeat expansion size categories significantly associated with ALS (Fisher’s exact test p<2.4×10−3). ALS, amyotrophic lateral sclerosis.
