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. 2021 Jun 24;92(11):1197–1205. doi: 10.1136/jnnp-2021-326854

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Tract-based white matter changes in ALS as identified by FA, AD and RD alterations at p<0.01 TFCE adjusted for age and gender. Changes in ALS-C9 are indicated in blue (top), and changes in ALS-NEG are shown in red-yellow (bottom). The Diedrichsen probabilistic cerebellar atlas is presented as underlay to aid localisation. MNI coordinates are provided on the right side of the figure for sagittal (x), coronal (y) and axial (z) views. AD, axial diffusivity; ALS, amyotrophic lateral sclerosis; ALS-C9, patients who tested positive for GGGGCC repeat expansions in C9orf72; ALS-NEG, patients who tested negative for both ATXN2 and C9orf72; FA, fractional anisotropy; MNI, Montreal Neurological Institute; RD, radial diffusivity; TFCE, threshold-free cluster enhancement.