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. 2021 Jun 24;92(11):1197–1205. doi: 10.1136/jnnp-2021-326854

Table 2.

Cerebellar grey matter volumes in HC and ALS-NEG and ALS-C9

Cerebellar grey matter Estimated marginal mean±SE for groups Statistics
Controls, n=110 ALS-NEG, n=133 ALS-C9, n=22 Univariate effect size HC vs ALS-NEG HC vs ALS-C9
Left
lobules*		 I–II 0.030±0.001 0.029±0.001 0.030±0.002 η2p=0.000 1.000 1.000
III 0.505±0.011 0.483±0.010 0.518±0.026 η2p=0.011 0.484 1.000
IV 2.080±0.029 1.984±0.026 1.844±0.065 η2p=0.049 0.045 0.003
V 3.590±0.047 3.612±0.042 3.394±0.106 η2p=0.014 1.000 0.276
VI 7.880±0.101 7.946±0.092 7.822±0.231 η2p=0.001 1.000 1.000
VIIB 4.031±0.059 3.944±0.054 3.782±0.135 η2p=0.012 0.851 0.286
VIIIA 4.921±0.062 5.017±0.057 5.015±0.142 η2p=0.005 0.767 1.000
VIIIB 3.334±0.053 3.476±0.048 3.294±0.121 η2p=0.018 0.155 1.000
IX 2.672±0.045 2.719±0.041 2.638±0.102 η2p=0.003 1.000 1.000
X 0.584±0.007 0.573±0.007 0.592±0.017 η2p=0.007 0.816 1.000
Crus I 11.106±0.153 10.760±0.140 10.371±0.350 η2p=0.019 0.300 0.169
Crus II 6.893±0.099 6.782±0.090 6.551±0.225 η2p=0.008 1.000 0.500
Right
lobules†		 I–II 0.035±0.001 0.037±0.001 0.039±0.002 η2p=0.012 0.711 0.305
III 0.495±0.010 0.480±0.009 0.506±0.024 η2p=0.006 0.896 1.000
IV 1.950±0.029 1.846±0.027 1.891±0.067 η2p=0.025 0.030 1.000
V 3.317±0.045 3.349±0.041 3.214±0.103 η2p=0.006 1.000 1.000
VI 7.873±0.102 7.892±0.093 7.519±0.233 η2p=0.009 1.000 0.495
VIIB 4.210±0.061 4.089±0.056 3.852±0.140 η2p=0.023 0.450 0.061
VIIIA 4.821±0.064 4.906±0.058 4.691±0.146 η2p=0.009 0.980 1.000
VIIIB 3.411±0.058 3.505±0.053 3.370±0.133 η2p=0.007 0.708 1.000
IX 2.836±0.045 2.893±0.041 2.809±0.102 η2p=0.004 1.000 1.000
X 0.582±0.007 0.566±0.007 0.588±0.017 η2p=0.013 0.292 1.000
Crus I 11.108±0.149 10.797±0.136 10.566±0.340 η2p=0.013 0.380 0.436
Crus II 7.088±0.103 6.954±0.094 6.985±0.235 η2p=0.004 1.000 1.000

Estimated marginal mean±SE for grey matter volumes adjusted for age, gender and total intracranial volume.

Bold p values are significant at p<0.05 after Bonferroni correction for multiple comparisons.

Partial η2 effect size is interpreted as small (η2p=0.01), medium (η2p=0.06) or large (η2p=0.14).

*Wilks’ lambda=0.854; F=1.695; p=0.022; η2p=0.076.

†Wilks’ lambda=0.857; F=1.662; p=0.026; η2p=0.074.

ALS, amyotrophic lateral sclerosis; ALS-C9, patients who tested positive for GGGGCC repeat expansions in C9orf72; ALS-NEG, patients who tested negative for both ATXN2 and C9orf72; HC, healthy control.