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. Author manuscript; available in PMC: 2021 Oct 18.
Published in final edited form as: Nature. 2021 Jan 20;591(7850):426–430. doi: 10.1038/s41586-020-03154-y

Extended Data Fig 4. Multiple epochs of TrpA1 stimulation extend the suppression of memory expression.

Extended Data Fig 4.

a, Memory rapidly recovered after a brief bout of TrpA1 stimulation. b, PSD-LTM retention across 14 d after spaced conditioning without PPL1-α2α’2 stimulation. c, PSD-LTM expression was significantly dampened at 3 d after a single 6 h bout of TrpA1 stimulation but resurfaced at 6 d. d, Three 6 h spaced TrpA1 stimulations prolonged the memory expression deficit to 10 d, but PSD-LTM expression resurfaced to normal levels at 14 d. Box-and-whisker plots show the range of individual data points, the interquartile spread as the box, and the median as the line bisecting each box. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001; n = 8 (a), one-way ANOVA with Dunnett’s post-hoc test; n = 6 (b), n = 12 (c, d), two-way ANOVA with Tukey’s test. Exact P-values and comparisons are shown in Supplementary Information.