Fig. 1.

Topology of Didelphidae from Jansa and Voss (2011) with the addition of Monodelphis domestica according to Pavan et al. (2014). Branch lengths reprisent the estimated number of amino acid substitions in vWF reconstructed with the JTT model of amino acid substitution available in PAML (Yang, 2007). The clade Didelphini, known for both organismal venom resistance as well accelerated evolution of vWF, is shown in red (light grey in black and white prints). Species used for this work are highlighted in blue (dark grey in black and white prints). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)