Fig. 2 |. Identification of APP gencDNA sequences in ten new whole-exome pull-down datasets from two independent laboratories.

a, Method schematic depicting the standard protocol for whole-exome pull-downs and highlighted methodological differences between the independent laboratories (our lab and Park et al.⁴). b, APP-751 sequence with non-duplicate gencDNA reads from the ten new datasets; colour key indicates the source reads for all panels. c, Reads that map to junctions between APP exons 7, 8, and 9 that are absent from APP-751. d, e, Paired reads that represent a DNA fragment containing both an exon–exon junction and an APP 3′ or 5′ UTR.