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Preparation of TM-Fc conjugates (ADCs). hIgG1 Fc was acylated via lysine residues with a PEG4 linker terminating in an azido group. Cu(I)-catalyzed cycloaddition with an alkyne-derivatized TM (click reaction) joins the Fc and TM via a 1,2,3-triazole linkage to provide the final conjugate.
