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. 2021 Oct 18;65(11):e00985-21. doi: 10.1128/AAC.00985-21

FIG 4.

FIG 4

ADCs show immunoprophylactic efficacy in COL-S and COL-R models of infection. Independent experiments examining the efficacy of (A) CTC-171 and (B) CTC-173, where “control 1h” is the bacterial burden in the thigh at 1 h postinfection and burdens of all other groups are at 48 h postinfection. All burdens are shown as CFU for each thigh. (C) Data from separate infections evaluating efficacy of CTC-171-CTC-174 in COL-S AB 482 normalized as a percentage of vehicle control for each independent experiment. (D) Data from separate infections evaluating efficacy of CTC-171, CTC-172, and CTC-173 in COL-R AB 317 normalized as a percentage of the vehicle control for each independent experiment. (E) Weight of each mouse as a percentage of day of infection demonstrates no significant weight loss in ADC-treated groups relative to vehicle or colistin controls. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. n = 3 to 5 for each experiment.