TABLE 1.
TMs selected for conjugation inhibit growth across KAPE G– strainsa
| TM | Geometric mean MIC (μg/ml) of select TMs of: |
Corresponding ADC | |||
|---|---|---|---|---|---|
| K. pneumoniae (μg/ml) (range) | A. baumannii (μg/ml) (range) | P. aeruginosa (μg/ml) (range) | E. coli (μg/ml) (range) | ||
| Colistin | 0.25 (0.125–64) | 8 (0.3–128) | 0.25 (0.125–2) | 0.25 (0.125–0.5) | |
| H-0009 | 1.70 (1–4) | 0.67 (0.5–2) | 1.38 (1–4) | 1.17 (1–2) | CTC-172 |
| H-0010 | 1.45 (0.5–4) | 0.59 (0.5–2) | 1.05 (0.5–2) | 1.05 (1–2) | CTC-173 |
| H-0027 | 0.72 (0.3–2) | 0.52 (0.3–2) | 1.12 (0.5–4) | 0.58 (0.5–1) | CTC-174 |
| H-0028 | 2.00 (0.5–8) | 1.12 (0.5–4) | 2.00 (1–8) | 0.85 (0.5–2) | CTC-171 |
a
Twelve clinical strains of K. pneumoniae, A. baumannii, P. aeruginosa, and E. coli were evaluated for MICs using the CLSI broth microdilution method.