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Immunoprophylactic efficacy linked with drug exposurea
| Compound | 24-h AUC/MIC | Burden reduction (%) (SD) |
|---|---|---|
| CTC-171 | 12.1 | 87.3 (8.9) |
| CTC-172 | 3.1 | 32.0 (50.5) |
| CTC-173 | 8.5 | 40.9 (30.4) |
| CTC-174 | 8.8 | 56.4 (34.9) |
Average AB 482 and AB 317 24-h AUC/MIC values from Table 3 and percentage bacterial burden reduction calculated from bacterial burdens of AB 482- and AB 317-infected mice relative to PBS-treated control for each infection.
