TABLE 2.
Single-dose plasma total drug pharmacokinetic parameters of meropenem/piperacillin/tazobactam after intravenous 1-h infusion administration at 200/300/200 mg/kg, 400/600/400 mg/kg, and 600/900/600 mg/kg to healthy New Zealand White rabbits
| Dose (mg/kg Q4h) | Mean AUC0–4 (μg · h/ml) ± SEM | Mean Cmax (μg/ml) ± SEM | Mean CL (ml/h/kg) ± SEM | Mean V (liters/kg) ± SEM |
|---|---|---|---|---|
| Meropenem | ||||
| 200 | 284.8 ± 22.8 | 229.9 ± 20.0 | 715.7 ± 59.2 | 281.3 ± 27.2 |
| 400 | 746.4 ± 25.9 | 716.9 ± 91.5 | 536.8 ± 17.8 | 455.4 ± 271.2 |
| 600 | 782.6 ± 78.5 | 690.1 ± 93.3 | 787.0 ± 69.3 | 332.1 ± 41.1 |
| Piperacillin | ||||
| 300 | 456.9 ± 81.7 | 483.5 ± 46.3 | 734.2 ± 147.8 | 230.1 ± 38.5 |
| 600 | 1,550.3 ± 113.3 | 1,245.8 ± 130.7 | 392.1 ± 31.3 | 183.8 ± 12.5 |
| 900 | 1,554.3 ± 104.1 | 1,096.9 ± 120.1 | 585.4 ± 41.8 | 464.51 ± 73.7 |
| Tazobactam | ||||
| 200 | 483.0 ± 78.7 | 425.6 ± 62.3 | 450.8 ± 75.8 | 194.3 ± 21.8 |
| 400 | 1,235.4 ± 84.13 | 990.2 ± 53.1 | 327.7 ± 23.6 | 178.1 ± 14.9 |
| 600 | 1,084.8 ± 103.9 | 722.4 ± 96.6 | 569.3 ± 59.6 | 558.2 ± 116.8 |