TABLE 1.

Mutations detected in a global sample of MTBC clinical isolates^a

Mutation position	Variant name	Gene position	Mutation type	Codon position	No. of isolates	No. of sublineages
776210	mmpL5 C2271A	2271	N	Y757*	2	2
777499	mmpL5 C982T	982	N	R328*	2	2
777581	mmpL5 C900A	900	N	Y300*	293	2
778086	mmpL5 395insC	395	Ins	132	6	2
779127	mmpR 138insG	138	Ins	46	5	4
779181	mmpR 192-198delG	192	Del	64	20	4
779181	mmpR 192-198insG	192	Ins	64	86	2
779407	mmpR 418insG	418	Ins	140	6	1
2714753	eis C580T	580	N	Q194*	10	2
2715287	eis 46insC	46	Ins	16	3	2
2715305	eis G28T	28	N	E10*	6	2
2715330	eis G3A	3	S	V1V	6	2
2715342	eis G-10A	−10 eis	I		293	18
2715344	eis C-12T	−12 eis	I		332	17
2715346	eis C-14T	−14 eis	I		181	19
2715369	eis G-37T	−37 eis	I		285	8
2726105	ahpC G-88A	−88 ahpC	I		3,350	12
2726141	ahpC C-52A	−52 ahpC	I		91	10
2726141	ahpC C-52T	−52 ahpC	I		92	25
2726145	ahpC G-48A	−48 ahpC	I		85	20
3568487	whiB7 193insG	193	Ins	65	3	3
3568488	whiB7 192delC	192	Del	64	573	3
3568547	whiB7 133delCA	133	Del	45	2	2
3568626	whiB7 54delA	54	Del	18	61	2
3568779	whiB7 T-100C	−100 whiB7	I		256	2
3568857	whiB7 C-178T	−178 whiB7	I		73	2
3568921	whiB7 G-242C	−242 whiB7	I		117	2
3569029	whiB7 A-350G	−350 whiB7	I		249	3

^aMutations that occur in our sample of 31,440 clinical isolates within the mmpL5, mmpS5, mmpR, ahpC, eis, and whiB7 coding sequences and the oxyR-ahpC, eis-Rv2417c, whiB7-uvrD2 intergenic regions are shown (Fig. 1). Mutations in regulator regions (mmpR, oxyR-ahpC, eis-Rv2417c, and whiB7-uvrD2) reported in this table were among the four most commonly detected variants in each region. Mutations in regulated regions (mmpL5, mmpS5, ahpC, eis, and whiB7) reported in this table were present in at least two MTBC sublineages. The full set of mutations detected within these genomic regions is reported in Table S1 in the supplemental material. S, synonymous; N, nonsynonymous; I, intergenic.