FIG 6.

Viremia and spleen viral load in DENV-infected mice treated with AT-752. AG129 mice challenged with DENV2 were treated orally with vehicle (control) or AT-752 (1,000 mg/kg loading dose 4 h prior to challenge, followed by BID doses of 500 mg/kg for 7 consecutive days, starting 1 h postinoculation). Blood and spleen samples were collected on days 4, 6, 7, 8, and 10 postinfection and assessed for viral load by a plaque assay described in Materials and Methods. Dotted lines indicate the limit of detection; data are expressed as means ± SDs. *, P ≤ 0.01 by t test at each time point.