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Bacterial burden (log CFU) in the lungs of Mtb-infected mice for the different dosing regimens with same weekly dose (top line). Doses are provided in milligrams per kilogram. Open circles represent observed log CFU values, red circles are mean values of the observed CFU data, and blue lines represent 95% confidence intervals around the observed values. The gray shaded area is the 95% confidence interval for PK/PD model-based simulated values.
