TABLE 1.
Parameter estimates of final population PK modela
| Parameters | Typical estimate (% RSE) |
Random variabilityb (% RSE) [% shrinkage] |
||
|---|---|---|---|---|
| Healthy | Infected | Healthy | Infected | |
| Ka (h−1) | 14.0 (12) | 15.4 (8) | ||
| Vc/F (liters/kg) | 0.205 (5) | 0.217 (3) | ||
| Vp/F (liters/kg) | 0.145 (16) | 0.160 (12) | ||
| CL/F (liters/h/kg) | 0.701 (2) | 0.697 (2) | 14.6 (30) [17] | 13.2 (24) [59] |
| Q/F (liters/h/kg) | 0.0105 (16) | 0.0089 (6) | ||
| RUV | 12.3 (35) [44] | 60.0 (8) [4] | ||
a
Abbreviations: Ka, absorption rate constant; Vc/F, volume of central compartment corrected for bioavailability; Vp/F, volume of peripheral compartment corrected for bioavailability; CL/F, clearance corrected for bioavailability; Q/F, intercompartmental clearance corrected for bioavailability; RSE, relative standard error.
b
Expressed as percent coefficient of variation of between-animal variability or residual unexplained variability (RUV).