TABLE 2.
Parameter estimates describing the in vivo natural growth kinetics of Mtb in BALB/c micea
Parameter | Typical estimate (% RSE) [% shrinkage] | Half-life (days) |
---|---|---|
Kgs (h−1) | 0.0357 (4) | 0.809 |
Log Nmax | 6.11 (1) | |
Log CFUinitialb | 1.77 (3) | |
RUV | 0.437 (11) [4] |
Abbreviations: Kgs, first-order growth rate constant; log Nmax, decadic logarithm of the maximum number of bacteria; log CFUinitial, inoculum size on day 1; RUV, standard deviation of residual unexplained variability in log CFU; RSE, relative standard error.
Initial inoculum in experiments for natural growth curve assessment. In studies 1 and 2, the values were 2.28 and 2.07, respectively.