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. 2021 Oct 18;65(11):e01744-20. doi: 10.1128/AAC.01744-20

TABLE 2.

Parameter estimates describing the in vivo natural growth kinetics of Mtb in BALB/c micea

Parameter Typical estimate (% RSE) [% shrinkage] Half-life (days)
Kgs (h−1) 0.0357 (4) 0.809
Log Nmax 6.11 (1)
Log CFUinitialb 1.77 (3)
RUV 0.437 (11) [4]
a

Abbreviations: Kgs, first-order growth rate constant; log Nmax, decadic logarithm of the maximum number of bacteria; log CFUinitial, inoculum size on day 1; RUV, standard deviation of residual unexplained variability in log CFU; RSE, relative standard error.

b

Initial inoculum in experiments for natural growth curve assessment. In studies 1 and 2, the values were 2.28 and 2.07, respectively.