TABLE 3.
Parameter estimates with bootstrap result for final PK/PD modela
| Parameter | Typical estimate (% RSE) | Half-life (days) | Bootstrap-derived median (90% CI) |
|---|---|---|---|
| Kkillmax (h−1) | 0.0374 (5.3) | 0.772 | 0.0370 (0.0350–0.0410) |
| EC50 (μg/ml) | 79.6 (60.2) | 79.6 (42.4–141.3) | |
| γ | 1.58 (23.1) | 1.64 (1.06–2.42) | |
| KPAE (h−1) | 0.0142 (74.6) | 2.03 | 0.0147 (0.0048–0.0254) |
| Study-specific coefficient for Kkillmaxb | 1.15 (4.0) | 1.15 (1.08–1.23) | |
| RUV1 | 0.284 (12.1) | 0.279 (25.0–30.7) | |
| RUV2 | 0.173 (27.2) | 16.3 (12.4–20.8) |
a
Abbreviations: Kkillmax, maximum kill rate induced by spectinamide 1810; EC50, concentration of spectinamide 1810 at half of Kkillmax; γ, Hill coefficient; KPAE, first-order rate constant for dissipation of postantibiotic effect; RUV1 and RUV2, standard deviations of residual unexplained variability in log CFU for study 1 and study 2, respectively.
b
Fold difference in Kkillmax in study 2 relative to study 1.