TABLE 5.
Dosing frequency | Regimen used to achieve a daily dose (mg/kg) of: |
||||||||
---|---|---|---|---|---|---|---|---|---|
20 | 40 | 100 | 166 | 200 | 333 | 400 | 600 | 800 | |
Study 1 | |||||||||
5× per wk (M–F) twice | 10 BID | 20 BID | 50 BID | 100 BID | 200 BID | 300 BID | 400 BID | ||
5× per wk (M–F) | 20 QD | 40 QD | 100 QD | 200 QD | 400 QD | ||||
3× per wk (M, W, F) | 20 TIW | 40 TIW | 100 TIW | 200 TIW | 400 TIW | ||||
2× per wk (M, R) | 20 BIW | 40 BIW | 100 BIW | 200 BIW | |||||
1× per wk (M) | 20 QW | 40 QW | 100 QW | ||||||
Study 2 | |||||||||
5× per wk (M–F) twice | 50 BID | 200 BID | |||||||
5× per wk (M–F) | 100 QD | ||||||||
3× per wk (M, W, F) | 166 TIW | 333 TIW |
Abbreviations: M, Monday; T, Tuesday; W, Wednesday; R, Thursday; F, Friday; BID, twice daily; QD, once daily; TIW, three times weekly; BIW, twice weekly; QW, once weekly.