TABLE 3.
Comparison of rpoB mutations between RMR and MDR isolates and description of the confidence level for specific RR-conferring mutationsa
| Confidence classification and rpoB RR-conferring mutation(s) | No. (%) of isolates |
P valueb | |
|---|---|---|---|
| RMR (n = 230) | MDR (n = 889) | ||
| High | |||
| S450L | 73 (31.7) | 625 (70.3) | <0.0001 |
| D435V | 2 (0.9) | 76 (8.5) | <0.0001 |
| H445Y | 37 (16.1) | 25 (2.8) | <0.0001 |
| H445D | 18 (7.8) | 28 (3.1) | 0.0015 |
| H445L | 9 | 10 | |
| D435F | 12 | 1 | |
| H445R | 3 | 3 | |
| S450F | 0 | 6 | |
| T400A, S450L | 0 | 6 | |
| S450W | 1 | 4 | |
| S450W, H445N | 0 | 5 | |
| Q432P | 0 | 4 | |
| Q432L | 0 | 3 | |
| Q432K | 0 | 3 | |
| S431G, D435G | 0 | 3 | |
| D435G, L430P | 0 | 2 | |
| H445Y, D435Y | 1 | 1 | |
| I452P, H445D | 2 | 0 | |
| D435A | 1 | 0 | |
| D435G | 1 | 0 | |
| D435V, L430P | 1 | 0 | |
| D435V, L452P | 0 | 1 | |
| D435V, S450L | 0 | 1 | |
| H445G | 0 | 1 | |
| I491F, S450L | 1 | 0 | |
| S431T, L430P | 0 | 1 | |
| S450Y | 0 | 1 | |
| V170F, S450L | 0 | 1 | |
| Total | 162 (70.4) | 811 (90.2) | <0.0001 |
| Moderate | |||
| L452P | 16 (7.0) | 28 (3.2) | 0.014 |
| D435Y | 7 (3.0) | 30 (3.4) | 0.83 |
| S441L | 6 | 0 | |
| D435Y, S428T | 0 | 1 | |
| L430R, D435Y | 0 | 1 | |
| L452P, L430P | 1 | 0 | |
| M434I, D435Y | 0 | 1 | |
| P454H, D435Y | 0 | 1 | |
| Total | 30 (13.0) | 62 (7.0) | 0.0046 |
| Minimal | |||
| L430P | 32 (13.9) | 10 (1.1) | <0.0001 |
| H445N | 3 | 2 | |
| I491F | 0 | 1 | |
| Total | 35 (15.2) | 13 (1.5) | <0.0001 |
| Unclassified | |||
| Del1306 | 2 | 0 | |
| Del1295 | 0 | 1 | |
| Del1302 | 0 | 1 | |
| R448K | 0 | 1 | |
| T427A | 1 | 0 | |
| Total | 3 | 3 | |
a
Where >1 mutation was identified, the highest confidence mutation was specified.
b
Chi-squared for difference in proportions.