TABLE 6.

Quantitative phenotypic DST for rifampin by rpoB mutation among 25 RR isolates

rpoB mutation	Confidence level	WGS DR profile	Rifampin MIC (μg/ml)	No. of isolates
L430P	Minimal	RMR	0.125a	4
L430P	Minimal	RMR	0.25a	2
L430P	Minimal	RMR	0.5a	1
L430P	Minimal	RMR	1a	1
L430P	Minimal	MDR	1a	2
H445N	Minimal	MDR	20	2
I491F	Minimal	MDR	1a	1
S441L	Moderate	RMR	10	2
D435Y	Moderate	RMR	1a	2
D435Y	Moderate	MDR	2	2
L452P	Moderate	RMR	0.5a	2
L452P	Moderate	MDR	2	3
L452P	Moderate	MDR	10	1

^aPhenotypically rifampin susceptible based on critical concentration of 1.0 μg/ml.