FIGURE 1.

Figure shows the interaction between different cytokines and JAK pairings and resultant physiologic effects in both healthy and disease states. Normal cytokine signaling through JAK pairs is essential for bodily functions such as providing immunity against pathogens and hematopoiesis. In inflammatory bowel disease, an exaggerated immune response leads to excessive signaling through the JAK-STAT pathway, resulting in overexpression of proinflammatory cytokines and a cycle of chronic, relapsing gastrointestinal inflammation and potential damage.