TABLE 1.

Table Summarizing Known Drugs That Target Metabolism to Treat IBD

Drug	Impact Upon Metabolic Signaling	Consequence for Metabolic Pathways
Immunosuppressants (eg, methotrexate)	Activates AMPK, blocks mTORC1	Increases OXPHOS
Corticosteroids	Blocks mTORC1	Inhibits glycolysis
Aminosalicylates	Blocks mTORC1	Inhibits glycolysis
Tacrolimus, everolimus, sirolimus	Blocks mTORC1	Inhibits glycolysis