Table 2.
Treatment Studies for Men Infected With Trichomonas vaginalis
| Authors (Year Published) [Supplementary Reference] | Study Objective | Study Design | Clinical Efficacy | Microbiological Efficacy |
|---|---|---|---|---|
| Sena et al (2012) [84s] | Assess predictors of persistence of STIs associated with NGU (including TV) following treatment among men in multiple STI clinics in the United States | RCT (13 men with T. vaginalis received doxycycline and TDZ) | NR | TDZ: 92.3%a |
| Khrianin and Reshetnikov (2006) [81s] | Compare efficacy of single-dose MTZ and ornidazole in treatment of urogenital trichomoniasis in men in Russia | RCT (210 men received MTZ, 217 received ornidazole)b | MTZ: 57.6%; ornidazole: 94.5% | MTZ: 77.1%; ornidazole: 98.2% |
| Ozbilgin et al (1994) [87s] | Assess efficacy of 5-nitroimidazoles (ornidazole, MTZ, SEC) in treating trichomoniasis in men in Egypt | RCT (85 men with trichomoniasis were treated with ornidazole [n = 26], MTZ [n = 29], or SEC [n = 30]) | 100% in all groups | 100% in all groups |
| Latif et al (1987) [82s] | Ascertain the prevalence of confirmed trichomoniasis among men attending STD clinics in Zimbabwe | Prospective cohort (218 men enrolled with positive T. vaginalis culture, 38 received single-dose MTZ and 15 received MTZ 400 mg × 5 days) | Single-dose MTZ: 57.1% asymptomatic after treatment; 5 days MTZ: 100% asymptomatic after treatment |
NRc |
| Kawamura (1978) [83s] | Compare efficacy of single-dose TDZ 1 g versus MTZ 1.5 g in men with trichomoniasis attending urology clinic in Japan | RCT (39 men received TDZ, 34 men received MTZ) | NR | TDZ: 100%d
MTZ: 100%d |
Abbreviations: MTZ, metronidazole; NGU, nongonococcal urethritis; NR, not reported; PCR, polymerase chain reaction; RCT, randomized controlled trial; SEC, secnidazole; STD, sexually transmitted disease; STI, sexually transmitted infection; TDZ, tinidazole; TV, Trichomonas vaginalis.
aNegative PCR 3–4 weeks after treatment.
bSide effects more common in MTZ group compared with ornidazole group (59.0% vs 3.7%).
cNo follow-up microbiologic testing performed.
dNegative T. vaginalis culture at 14 and 30 days after treatment.