Table 1.

First-tier metabolic and routine chemistry tests as part of TIDE protocol

Biochemical genetics laboratory metabolic tests	Routine chemistry tests
1. Plasma amino acids	Ammonia
2. Urine organic acids	Copper/ceruloplasmin
3. Dried blood spot acylcarnitines	Homocysteine
4. Urine purine, pyrimidine, creatine metabolites	Lactate