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. 2021 Oct;105:101–119. doi: 10.1016/j.reprotox.2021.08.007

Fig. 10.

Fig. 10

(A) Heatmap summarizing the effects of 14d treatment with mixtures tested in our previous study [31] (i.e., 3-Sim: BPA + CPF + Lead; 3-Diss: Methyl-Hg + PCB138+VA; 6-All: BPA + CPF + Lead + Methyl-Hg + PCB138+VA) in comparison with mixtures tested in this study (i.e., 5-Sim: BPA + CPF + Lead + BDE47+EtOH; 5-Diss: Methyl-Hg + PCB138+VA + Vincl + TCDD; 10-All: BPA + CPF + Lead + BDE47+EtOH + Methyl-Hg + PCB138+VA + Vincl + TCDD). Delta values (% difference vs solvent control) between indicated representative LOAECs are displayed (different colours refer to ranges of delta values, orange: increase; blue: decrease). Asterisks indicate statistical significance compared to solvent control (* p < 0.05, ** p < 0.01, *** p < 0.001). (B) Correlation plot summarizing the overall effects (i.e., Delta values, % difference vs control) considering mixtures’ effects on all the DNT endpoints at the concentrations shown in A. The correlation matrix was calculated using Pearson and visualized using Rcorrplot package. Size and colour of the circles corresponds to the level of correlation between pair-wise mixtures: i.e., the bigger and darker green, the higher the level of correlation.