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. 2021 Oct;105:101–119. doi: 10.1016/j.reprotox.2021.08.007

Table 2.

LOAECs specific for each DNT endpoint and their serial dilutions. These nominal concentrations (in μM) were used to prepare the three mixtures described in Materials and Methods.

BPA CPF Lead BDE-47 EtOH Methyl-Hg PCB-138 VA Vincl TCDD (μM)
BDNF 12.74 37.10 1.46 0.20 106,810 0.13 3.53 210 0.42 0.60 LOAEC-bdnf
6.37 18.55 0.73 0.10 53,405 0.07 1.77 105 0.21 0.30 LOAEC/2-bdnf
3.19 9.28 0.37 0.05 26,703 0.03 0.88 52.5 0.11 0.15 LOAEC/4-bdnf
1.59 4.64 0.18 0.02 13,351 0.017 0.44 26.25 0.05 0.08 LOAEC/8-bdnf
Neurite Outgrowth 12.74 37.1 1.46 0.20 170,000 0.13 11.86 420 5.31 0.04 LOAEC-neu
6.37 18.55 0.73 0.10 85,000 0.07 5.93 210 2.66 0.02 LOAEC/2-neu
3.19 9.28 0.37 0.05 42,500 0.03 2.97 105 1.33 0.01 LOAEC/4-neu
1.59 4.64 0.18 0.02 21,250 0.016 1.48 52.5 0.66 0.005 LOAEC/8-neu
Synaptogenesis 12.74 21.01 0.0073 17.62 106,810 0.05 0.06 2.1 0.42 0.60 LOAEC-syn
6.37 10.51 0.0037 8.81 53,405 0.025 0.03 1.05 0.21 0.30 LOAEC/2-syn
3.19 5.25 0.0018 4.41 26,703 0.013 0.015 0.53 0.11 0.15 LOAEC/4-syn
1.59 2.63 0.0009 2.20 13,351 0.006 0.0074 0.26 0.05 0.08 LOAEC/8-syn