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. 2021 Oct;105:72–90. doi: 10.1016/j.reprotox.2021.08.003

Fig. 12.

Fig. 12

Ibuprofen Exposure. (a) Literature-based exposure limits in different species in [μM] (o/o no effect/ NOAEL; o/o teratogenic/ LOAEL, see Suppl. Fig. S1). (b-c) E14Tg2A (b) and T/Bra::GFP (c) mouse gastruloids at 120 h, following exposure to DMSO (vehicle control) or ibuprofen (IB). Color indicates fluorescent expression of T/Bra::GFP (blue). Representative images from 2 replicates shown. (d) RUES2-GLR human gastruloids at 72 h, following exposure to DMSO or ibuprofen. Color indicates fluorescent expression of BRA-mCerulean (blue), SOX2-mCitrine (yellow) and SOX17-tdTomato (red). Representative images from 1 replicate shown. Scale bars represent 200 μm (b,c) and 100 μm (d). Rep, Replicate. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article).