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. 2021 Oct 18;37(1):168–175. doi: 10.1007/s11606-021-07146-0

Table 4.

Outcomes in the General Cohort

Low/Intermediate risk High risk Very high risk
CS, N=951 CS+TCZ, N=54 p value CS, N=4381 CS+TCZ, N=554 p value CS, N=1542 CS+TCZ, N=238 p value
In-hospital death 85 (8.9) 4 (7.4) 1.000 1201 (27.4) 13 (20) <0.001 630 (40.9) 57 (23.9) <0.001
HFNC 59 (6.2) 16 (29.6) <0.001 452 (10.4) 156 (28.3) <0.001 192 (12.5) 74 (31.2) <0.001
NIMV 32 (3.4) 10 (18.5) <0.001 266 (6.1) 103 (18.6) <0.001 130 (8.4) 39 (16.4) <0.001
IMV 30 (3.2) 9 (16.7) <0.001 268 (6.1) 123 (22.2) <0.001 149 (9.7) 68 (28.6) <0.001
ICU 47 (4.9) 11 (20.4) <0.001 375 (8.6) 168 (30.3) <0.001 188 (12.2) 84 (35.3) <0.001
Length of stay (days), median [IQR] 8 [5–12] 12 [8–18.5] <0.001 9 [6–13] 14 [10–20] <0.001 9 [5–14] 15 [10–23] <0.001

HFNC high-flow nasal cannula, NIMV non-invasive mechanical ventilation, IMV invasive mechanical ventilation, ICU intensive care unit, IQR interquartile range, CS corticosteroids, CS+TCZ corticosteroids + tocilizumab