Table 6.
Risk Factors in the Matched-Cohort. High-Risk Category
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI) | p value | |
| Age | 1.07 (1.05–1.09) | <0.001 | 1.08 (1.06–1.09) | <0.001 |
| Gender (female) | 1.16 (0.74–1.81) | 0.525 | 0.69 (0.47–0.99) | 0.045 |
| BMI | 1.02 (0.98–1.06) | 0.405 | ||
| Race | NS | |||
| Caucasian (ref.) | 1 ref. | |||
| Black | 1.10 (0.90–1.15) | 0.999 | ||
| Hispanic | 0.46 (0.21–1.01) | 0.054 | ||
| Asian | 2.37 (0.15–38.14) | 0.543 | ||
| Others | 0.79 (0.16–3.96) | 0.774 | ||
| Moderate/severe dependency | 4.90 (2.77–8.68) | <0.001 | 1.98 (1.01–3.90) | 0.048 |
| Arterial hypertension | 2.33 (1.55–3.49) | <0.001 | NS | |
| Dyslipidemia | 1.75 (1.18–2.59) | 0.006 | NS | |
| Diabetes mellitus | 1.81 (1.15–2.83) | 0.010 | NS | |
| Ischaemic cardiopathy | 2.06 (1.08–3.93) | 0.028 | NS | |
| Chronic heart failure | 7.59 (2.90–19.83) | <0.001 | NS | |
| Chronic liver disease | 1.10 (0.42–2.93) | 0.845 | ||
| Severe chronic renal failure | 4.04 (1.41–11.57) | 0.009 | NS | |
| Dementia | 5.24 (0.95–28.97) | 0.057 | NS | |
| Cancer | 2.54 (1.41–4.59) | 0.002 | NS | |
| COPD | 2.49 (1.11–5.61) | 0.027 | NS | |
| Asthma | 0.58 (0.25–1.34) | 0.202 | ||
| OSAS | 1.67 (0.80–3.39) | 0.176 | ||
| Charlson index | 1.28 (1.15–1.43) | <0.001 | 1.14 (1.04–1.24) | 0.003 |
| Respiratory rate >20 rpm | 2.29 (1.49–3.54) | <0.001 | 2.01 (1.41–2.87) | <0.001 |
| PaO2/FiO2 | 0.99 (0.99–0.99) | <0.001 | 0.99 (0.99–0.99) | <0.001 |
| Tocilizumab | 0.67 (0.45–0.99) | 0.050 | 0.78 (0.56–1.09) | 0.150 |
BMI body mass index, NS not significant, COPD chronic obstructive pulmonary disease, OSAS obstructive sleep apnea syndrome