Table 2:
mIPSC properties during baseline and steady-state after vehicle or drug washin at different holding potentials.
| Vehicle (DMSO) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline (raw values) | Steady-state (raw values) | ||||||||
| HP (mV) | n | Frequency (Hz) | Amplitude (pA) | Decay (ms) | Charge (pA*ms) | Frequency (Hz) | Amplitude (pA) | Decay (ms) | Charge (pA*ms) |
| −60 | 6 | 2.7 ± 1.0 | 27.9 ± 2.2 | 17.5 ± 0.5 | 440 ± 40 | 2.9 ± 1.2 | 27.1 ± 2.1 | 18.7 ± 1.0* | 470 ± 50 |
| −30 | 6 | 0.8 ± 0.1 | 14.5 ± 0.6 | 17.3 ± 1.1 | 230 ± 20 | 1.1 ± 0.2 | 13.9 ± 0.5 | 18.6 ± 1.2 | 240 ± 20 |
| +30 | 6 | 0.9 ± 0.3 | 25.5 ± 3.2 | 26.1 ± 2.5 | 620 ±100 | 1.1 ± 0.3 | 20.7 ± 2.1 | 27.6 ± 2.5* | 530 ± 80 |
| Midazolam | |||||||||
| Baseline (raw values) | Steady-state (raw values) | ||||||||
| HP (mV) | n | Frequency (Hz) | Amplitude (pA) | Decay (ms) | Charge (pA*ms) | Frequency (Hz) | Amplitude (pA) | Decay (ms) | Charge (pA*ms) |
| −60 | 5 | 5.3 ± 2.5 | 25.1 ± 1.6 | 15.8 ± 1.6 | 350 ± 50 | 6.6 ± 3.0 | 30.5 ± 1.6** | 21.9 ± 2.0** | 500 ± 40** |
| −30 | 5 | 0.6 ± 0.1 | 14.5 ± 2.6 | 17.7 ± 1.3 | 240 ± 50 | 0.9 ± 0.2** | 15.1 ± 1.7 | 23.5 ± 1.4** | 320 ± 30* |
| +30 | 5 | 1.2 ± 0.2 | 26.2 ± 1.7 | 25.8 ± 0.6 | 600 ± 50 | 1.4 ± 0.3 | 24.9 ± 1.3 | 28.8 ± 0.9 | 650 ± 30 |
| Diazepam | |||||||||
| Baseline (raw values) | Steady-state (raw values) | ||||||||
| HP (mV) | n | Frequency (Hz) | Amplitude (pA) | Decay (ms) | Charge (pA*ms) | Frequency (Hz) | Amplitude (pA) | Decay (ms) | Charge (pA*ms) |
| −60 | 6 | 2.2 ± 0.3 | 30.3 ± 2.7 | 18.8 ± 1.5 | 510 ± 80 | 2.4 ± 0.4 | 29.5 ± 2.0 | 24.7 ± 2.2** | 660 ± 90* |
| +30 | 5 | 1.0 ± 0.1 | 24.9 ± 1.8 | 29.8 ± 1.4 | 670 ± 60 | 1.2 ± 0.1 | 21.5 ± 1.9** | 36.9 ± 1.4** | 720 ± 70** |
Values shown are mean ± SEM and were collected as described in Figure 2A. Holding potential (HP) during baseline and steady state potentials are shown as mean +/− SEM. Normalized values were derived as described in the legend of Figure 1. Values significantly different from baseline (paired Student’s t-test, * p < 0.05, ** p < 0.01).