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The flow of the data and the steps of the analysis. The subsets of data are named “Training”, “Validation/Discovery”, and “Replication”, according to the naming in the text. Orange color highlights steps of analysis where models were trained, blue color highlights steps of analysis where models were validated. The N = 5,179 subset of Inter99 was used both for the validation of the BMI PRS and for the discovery of the interactions with risk factors.
