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. 2021 Apr 6;385(2):405–422. doi: 10.1007/s00441-021-03429-4

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© The Author(s) 2021

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Fig. 2 — Molecular architecture of MN antigens/biomarkers. (a) PLA2R is a 180 kDa plasma membrane protein consisting of a cysteine-rich (CysR) domain, a fibronectin type II (FnII) domain, eight c-type lectin domains (CTLDs), one transmembrane region and a short cytoplasmic tail. (b) THSD7A is a 250 kDa plasma membrane protein consisting of twenty-one thrombospondin repeat (TSR) domains, which can be further classified as thrombospondin (THBS1)-like (blue) or F-spondin/C6-like (green), one transmembrane region and a short cytoplasmic tail. (c) EXT1 and EXT2 are proteins expressed in the endoplasmic reticulum membrane with a short cytoplasmic tail, one transmembrane region, short stem region and a long luminal tail. EXT1 contains a luminal catalytic domain. (d) NELL1 is a 90 kDa cytosolic protein containing a THBS1-like domain, one coiled-coil domain, 4 von Willebrandt (VW)-type domains and six epidermal growth factor-like (EGF-like) domains. (e) SEMA3B is a 80 kDa secreted protein containing a Sema domain, a plexin-semaphorinintegrin (PSI) domain, an immunoglobulin (IgG) domain and a basic domain