Table 4.

Differences in brain volumes between the NPSLE patients (ischemic and inflammatory) and the non-NPSLE patients and between NPSLE ischemic and NPSLE inflammatory patients

	Non-NPSLE patients (n = 117)	NPSLE inflammatory patients (n = 26)	NPSLE ischemic patients (n = 12)	NPSLE inflammatory vs non-NPSLE (B (95% CI))	NPSLE ischemic vs non-NPSLE (B (95% CI))	NPSLE inflammatory vs NPSLE ischemic (B (95% CI))
White matter volume	482 ± 57	468 ± 56	485 ± 51	−17.1 (−31.4 to −2.8)*	0.5 (−20 to 21)	−18.9 (−34.6 to −3.2)*
Grey matter volume	560 ± 61	555 ± 69	564 ± 44	−13.7 (−27.6 to 0.3)	2.6 (−16.1 to 21.3)	−17.5 (−42.5 to 7.5)
Total brain volume	1042 ± 111	1022 ± 118	1049 ± 100	−30.7 (−55 to −6.4)*	3.1 (−31.1 to 37.4)	−36.4 (−70.5 to −2.2)*
WMH volume	0.60 (0.11–5.04)	1.06 (0.11–17.46)	1.11 (0.11–8.27)	0.87 (0.33 to 1.41)*	0.24 (−0.46 to 0.94)	0.66 (−0.34 to 1.65)

The second, third, and fourth columns represent volumes of white matter, grey matter, and total brain and white matter hyperintensity (WMH) volume of non-NPSLE, NPSLE inflammatory, and NPSLE ischemic patients in ml and these volumes are expressed as means ± standard deviations or as median (10–90% confidence intervals)

The fifth, sixth, and seventh columns represent B values (95% confidence interval) of the linear regression analysis on brain and WMH volumes respectively in NPSLE inflammatory patients vs non-NPSLE patients, in NPSLE ischemic patients vs non-NPSLE patients, and in NPSLE inflammatory patients vs NPSLE ischemic patients adjusted for gender, age, and total intracranial volume

For the linear regression analysis, the WMH were multiplied by 1,000,000 and natural log transformed, because of non-normal distribution

*p < 0.05