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. 2021 Jan 26;385(2):305–322. doi: 10.1007/s00441-020-03351-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Mechanisms of Treg activation and depletion in immune-mediated GN. Treg activation and function is supported by IL-2, IL-10 and the IL-2/anti-IL-2 mAb complex in immune-mediated GN thereby suppressing the inflammatory Th1 and Th17 response. In contrast, Treg depletion due to IL-2 deficiency or blockage of CD25 increases Th1- and Th17-mediated immunity