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. 2021 Oct 18;11:20595. doi: 10.1038/s41598-021-99917-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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425 nm blue light exhibits dose-dependent activity against the betacoronavirus family. Independent laboratories exposed (A) 10⁶ TCID₅₀/mL SARS-CoV-1 (MRIGlobal), (B) 10⁶ PFU/mL MERS-CoV (EmitBio), or (C) 10⁶ PFU/mL human rhinovirus 1B (EmitBio) to the indicated doses of 425 nm blue light. Particles exposed to light were titered on Vero E6 (SARS-CoV-1), Vero CCL-81 (MERS-CoV), or H1 HeLa (HRV-1B) cells. Data are represented as ± SD. Statistical analysis was executed using a Mann–Whitney test wherein * is p < 0.05 and ** is p < 0.01 when compared to the 0 J/cm² control.