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. 2021 Oct 18;11:20570. doi: 10.1038/s41598-021-99891-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Histology (Masson’s trichrome stain) in wild type (WT), Lepr^db/db eNOS^−/− (2KO) and high fat diet plus low dose STZ-treated (HFD + STZ) mice. Low magnification view from all three models (A–C) indicate the absence of large areas of scar typically associated with myocardial infarction. Diffuse fibrosis (area within black dashed line) was only observed in 2KO mice (E,H). Each image is from a different tissue sample.