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. 2021 Oct 18;12:6058. doi: 10.1038/s41467-021-26343-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Workflow of sample composition, processing and bioinformatic analyses for 23 samples in the present study. b t-SNE plot of all high-quality cells profiled in the present study colored by major cell lineage. c, Heatmap of the canonical and curated marker genes for major cell lineages. d t-SNE projection showing the landscape of immune cells, colored by cluster (left) and tissue (right). e Tissue preference for each immune cell subcluster estimated by Ro/e. Source data are provided in the Source Data file.