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. 2021 Oct 18;12:6058. doi: 10.1038/s41467-021-26343-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a t-SNE projection showing five different subtypes of ECs. Expression levels of marker genes for arterial (b), venous (c), lymphatic (d), immature (e), and tip ECs (f). g Heatmap showing the TF activities in the five EC subtypes, scored by SCENIC and AUCell. h Sankey diagram showing assignment of normal EC (NEC) and tumor EC (TEC) to arterial, venous, lymphatic, immature and tip subtypes. i Bubble plots showing L-R pairs of cytokines, chemokines and growth factors between tip ECs and other cell types, inferred by CellPhoneDB. Source data are provided in the Source data file.