Fig. 1. Peripheral naive CD8⁺ T cells are phenotypically heterogeneous.

a Ly6C, CD183, and CD103 expression on B6 CD44^lo and CD44^hi CD8⁺ T cells. b Percentage of Ly6C⁺, CD183⁺, and CD103⁻ cells in CD5^lo and CD5^hi B6 naive CD8⁺ T cells (n = 12 mice for Ly6C⁺ and CD183⁺, n = 5 mice for CD103⁻). c Percentage of CD183⁺ and CD103⁻ cells in Ly6C⁻ and Ly6C⁺ CD5^hi B6 naive CD8⁺ T cells (n = 12 mice for CD183⁺, n = 7 mice for CD103⁻). d Percentage of CD183⁺ and Ly6C⁺ cells in CD24^hi, CD24^lo CD5^lo, and CD24^lo CD5^hi B6 CD4⁻CD8⁺ thymocytes (n = 12 mice for Ly6C⁺, n = 6 mice for CD183⁺). e Splenic and thymic Ly6C⁺ B6 naive CD8⁺ T cell changes over time after birth (n = 3 mice for each group). f Splenic and thymic Ly6C⁺ B6 naive CD8⁺ T cells in young and old mice (n = 3 mice for each group). Statistical significance was confirmed by two-tailed unpaired Student’s t-test. Results are shown as mean ± SD. Data representative of 2–3 independent experiments. Source data are provided as a Source data file.