Fig. 4. Type I IFN affects functional properties of Ly6C⁺ naive CD8⁺ T cells.

a IFN-γ production of CD5^lo, Ly6C⁻, and Ly6C⁺ B6 naive CD8⁺ T cells (n = 3 mice for each group). b IFN-γ production of CD5^lo and CD5^hi naive CD8⁺ T cells from WT or Ifnar^−/− mice (n = 6 mice for each group). c Relative IFN-γ production of CD5^lo, Ly6C⁻, induced Ly6C⁺ (inLy6C⁺) donor cells and host Ly6C⁺ cells (n = 4 mice for each group). d IFN-γ production of CD5^lo, Ly6C⁻, and Ly6C⁺ B6 naive CD8⁺ T cells pretreated with Control Ab or anti-IFNAR1 Ab in vivo (n = 6 mice for each group). Statistical significance was confirmed by two-tailed unpaired Student’s t-test. Results are shown as mean ± SD. Data representative of 2–3 independent experiments. Source data are provided as a Source data file.