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. 2021 Oct 18;12:6072. doi: 10.1038/s41467-021-26346-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A Clusters containing cells expressing known TM markers were isolated from the full dataset and reclustered in a new set of principal components. B, C Angpt1 expression in putative TM cell clusters from control and Angpt1ΔNC eyes. D Bars indicate cell cluster size as a percentage of total sequenced cells of each genotype. Noted percentages indicate relative abundance of each cluster in Angpt1ΔNC eyes compared to control sample. E–G Marker gene analysis in wild-type samples was used for cluster identification. E Cells in TM1 revealed features of keratinocytes while TM2 contained corneal endothelia. F TM4 and 5 exhibit an expression pattern consistent with trabecular meshwork or JCT cells. G TM10 contained Cd34+ cells which appeared to be corneal stromal cells. The expression pattern in TM11 was consistent with trabecular meshwork fibroblast like “beam” cells. (H) Svep1 expression in TM cell clusters. (I) Dendrogram highlighting the relationship between identified cell clusters.