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. 2021 Oct 18;12:6055. doi: 10.1038/s41467-021-26239-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A In vitro antiviral activity (EC₅₀), and cytotoxicity (CC₅₀) for PF-00835231 and PF-07304814 with and without the P-gp efflux inhibitor, CP-100356. n as shown reflects individual replicates (B) EC₅₀ values with PF-00835231 with increasing P-gp inhibitor in human lung and monkey kidney cell lines. A549-ACE2 human lung carcinoma data (red) as reported in ref. ¹⁸. Data are presented as mean±95% confidence interval as error bars.