Table 1.

Activity of PF-00835231 against 3CL^pro of coronaviruses (mean ± SEM).

Virus	Ki (nM)
Alpha-CoV
NL63-CoV	0.77 ± 0.52
HCoV-229E	1.5 ± 0.76
PEDV	0.30 ± 0.11
FIPV	0.12 ± 0.10
Beta-CoV
SARS-CoV-2a	0.27 ± 0.1
HKU1-CoV	0.85 ± 0.24
HKU4-CoV	0.034 ± 0.079
HKU5-CoV	0.033 ± 0.12
HKU9-CoV	0.74 ± 0.68
MHV-CoV	1.2 ± 0.90
OC43-CoV	0.51 ± 0.12
Gamma-CoV
IBV-CoV	4.0 ± 0.37

^aData reported in ref. ¹⁵.