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. 2021 Oct 18;11:20627. doi: 10.1038/s41598-021-99974-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Racemic lead structure 1 and structures of the 5-([2.2]paracyclophan-4-yl)-1-aryl-1,2,3-triazoles in their (S_p)- and (R_p)-configuration. The compounds were synthesized with different residues R: racemic compounds with R = H, F, OMe, Me, and NO₂, S_p and R_p-compounds with R = H, F and OMe each. Details on the structures and results can be retrieved from Supplementary File 1 online. (b) Dose–response study of racemic compound 18. Animals were treated in triplicates with the indicated concentration of the compound for 30 min. Nematocyst discharge was recorded by counting the fraction of artemia (out of ten) caught by each polyp after 15 min. The compound concentration is shown in the log scale. Colored areas correspond to standard deviation. IC50 values were determined by fitting logistic functions to the average inhibition (dashed lines) and solving them for 50% inhibition.