Table 1.

Structure–activity relationships of [2.2]paracyclophane derivatives.

No	Compound	Ranka	Nematocyst dischargeb		Toxicityc
			[50 µM]	[10 µM]	[10 µM]
1	1	1	0	0	N
2	4	–d	0	0	N
3	5	– d	3	10	N
4	6	0	0	10	Y
5	7	2	0	0	Y
6	8	0	7	10	N
7	9	– d	0	0	N
8	10	0	3	10	Y
9	11	0	0	0	N
10	12	3	10	10	N
11	13	0	10	10	N
12	14	1	0	10	N
13	15	0	0	7	N
14	16	1	0	0	N
15	17	– d	10	10	N

^aIndication after primary assay (10 µM): 0 = no prey capture in all animals tested (highly active) to 3 = prey capture in all animals as in control (no activity).

^bObservations were recorded as means of biological triplicates using a well of 10 animals according to 0 = nematocyst discharge in no animal (high effect) to 10 = nematocyst discharge in all animals (no effect).

^cToxicity was recorded after 24 h at a concentration of 10 µM: Y = toxicity observed, N = no toxicity observed; toxicity included categories 2–5 (see figure legend Fig. 1).

^dWas not included in the primary assay.