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. 2021 Oct 18;12:6054. doi: 10.1038/s41467-021-26250-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Psychophysiological interaction analysis indicated that while the connectivity between the inferior frontal gyrus (IFG) and hippocampus increased in the placebo (PLAC) group from 28d relative to 1d (p = 0.004 two-tailed Welch’s t-test), there was even a decrease in IFG-hippocampus connectivity at 28d compared to memory testing after 1d in the yohimbine (YOH) group (p = 0.020, two-tailed Welch’s t-test; drug × delay, SVC peak-level: x = −22, y = −40, z = −2, p(FWE) = 0.009, mixed ANOVA; n = 104 participants). Bonferroni correction was applied for the number of regions of interest in each analysis. The seed-region in the IFG (green), retrieved from the drug × delay interaction of the univariate analysis (peak: x = −50, y = 34, z = 12; k = 62), and the significant cluster in the hippocampus (orange) are superimposed on sagittal slices of T1-weighted template images. Distribution of beta-values for the significant cluster is presented for the contrast old > new. Bars represent mean ± SEM. Source data are provided as Source data file. *p < 0.050, **p < 0.010.