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. 2021 Oct 18;11:20608. doi: 10.1038/s41598-021-98931-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of chitosan on the inflammatory cytokines. (a) TNF-alpha (b) IL-10 (c) IL-6. Control: normal mice; HS: Heat stress mice; COS-LD: mice treated with HS plus COS (300 mg/kg); COS-MD: mice treated with HS plus COS (600 mg/kg); COS-HD: mice treated with HS plus COS (1000 mg/kg). Data are expressed as mean ± standard error. *Indicates p < 0.05 compared with the blank control group, ^#Indicates p < 0.05 compared with the HS control group.